Magnifying Endoscopic Diagnosis of Early Gastric Cancer and Superficial Neoplasm without Helicobacter pylori Infection:A Case Series Daisuke Yoshimura 1 , Rie Yoshimura 2 , Seiya Kato 3 , Takahiro Mizutani 1 , Toshiaki Ochiai 1 , Tomohito Chaen 1 , Shinichiro Fukuda 1 , Risa Iwao 1 , Kojiro Niho 1 , Kayoko Nakano 1 , Yusuke Kitagawa 1 , Kaoru Ichida 1 , Minako Izumi 1 , Eikichi Ihara 4 , Yoshihiro Ogawa 4 1Division of Gastroenterology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan 2Health Checkup Center Wellness, Fukuoka, Japan 3Division of Pathology, Saiseikai Fukuoka General Hospital, Fukuoka, Japan 4Medicine and Bioregulatory Science(The 3rd Department of Internal Medicine), Kyushu University, Fukuoka, Japan Keyword: H. pylori未感染胃癌 , 拡大内視鏡診断 , 超高分化型・低異型度腺癌 , BLI , blue laser imaging , NBI , narrow band imaging pp.234-245
Published Date 2019/2/25
DOI https://doi.org/10.11477/mf.1403201586
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 The present study was retrospective and aimed to investigate the magnifying endoscopic appearance of early gastric cancer without H. pylori(Helicobacter pylori)infection from April 2005 to June 2018. We included 40 patients who fulfilled the requirement of not being infected by HP in the diagnosis as well as endoscopic and histological examinations. Of these, 21 patients had very well differentiated adenocarcinomas of the gastric phenotype, whereas 19 had signet-ring cell carcinomas. Fundic gland type adenocarcinomas and signet ring cell carcinomas did not exhibit demarcation lines because their surfaces were covered with the normal foveolar epithelium. In addition, some highly differentiated adenocarcinomas of other gastric phenotypes exhibited only subtle irregularities of surface patterns because of their pathological characteristics. However, we conclude that elaborate magnifying endoscopy could potentially estimate the histopathological structures of such gastric type adenocarcinomas by detecting the subtle surface and vascular abnormalities.

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