Stomach and Intestine(Tokyo) Volume 54, Issue 7 (June 2019)

Relationship among Autoimmune Gastritis, H. pylori Infection and H. pylori Eradication Takahisa Furuta 1 , Mihoko Yamade 2 , Takahiro Uotani 2 , Takuma Kagami 2 , Tomohiro Higuchi 2 , Takahiro Suzuki 2 1Center for Clinical Research, Hamamatsu University Hospital, Hamamatsu, Japan 2First Department of Medicine, Hamamatsu University Hospital, Hamamatsu, Japan Keyword: 自己免疫性胃炎 , 泥沼除菌 , H. pylori pp.1036-1041
Published Date 2019/6/25
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 There are following two types of autoimmune gastritis(AIG):H. pylori-related AIG and H. pylori-unrelated AIG. These types of AIG significantly differ in terms of atrophy of the corpus callosum and chronic inflammation of the antrum. In both types of AIG, gastric acid secretion is remarkably impaired, allowing bacteria other than H. pylori to inhabit the stomach. Some of these bacteria have urease activity, leading to positive results of13C-UBT(13C-urea breath test). Because gastric-acid secretion is improved after the eradication in cases of H. pylori-induced gastritis, bacteria other than H. pylori have difficulty colonizing the stomach. However, in cases of H. pylori-related AIG, gastric-acid secretion is not restored after the eradication of H. pylori, allowing urease-positive bacteria to inhabit the stomach after the eradication. Therefore, the results of 13C-UBT remain positive and failure to eradicate H. pylori is diagnosed. This misdiagnosis leads to further eradication therapies or endless eradication(doronumajokin). In cases of H. pylori-unrelated AIG, the results of the 13C-UBT are also positive because of the above-mentioned reasons, leading to doronumajokin.

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54巻7号 (2019年6月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院