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Non-neoplastic Disease of the Small Intestine:Chronic Enteropathy Associated with the SLCO2A1 Gene(CEAS) Yuta Fuyuno 1 , Junji Umeno 1 , Atsushi Hirano 1 , Yoshifumi Hori 2 , Minako Fujiwara 2,3 , Yuji Maehata 4 , Hiroyuki Kobayashi 5 , Shuji Kochi 6 , Koichi Kurahara 7 , Shigeyoshi Yasukawa 8 , Fumihito Hirai 9,10 , Takehiro Torisu 1 , Motohiro Esaki 1,11 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Department of Health Science, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan 4Maehata Clinic, Kagoshima, Japan 5Institute of Gastroenterology, Fukuoka Sanno Hospital, Fukuoka, Japan 6Institute of Gastroenterology, Chihaya Hospital, Fukuoka, Japan 7Department of Gastroenterology, Matsuyama Red Cross Hospital, Matsuyama, Japan 8Institute of Gastroenterology Tanushimaru Central Hospital, Kurume, Japan 9Inflammatory Bowel Disease Center, Fukuoka University Chikushi Hospital, Chikushino, Japan 10Department of Gastroenterology, Fukuoka University Chikushi Hospital, Chikushino, Japan 11Department of Endoscopic Diagnostics and Therapeutics, Saga University Hospital, Saga, Japan Keyword: SLCO2A1遺伝子 , 非ステロイド性抗炎症薬 , NSAIDs , 肥厚性皮膚骨膜症 , プロスタグランジン関連腸症 , プロスタグランジン輸送体 pp.485-495
Published Date 2019/4/25
DOI https://doi.org/10.11477/mf.1403201623
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 CEAS(chronic enteropathy associated with the SLCO2A1 gene)is a rare, intractable, hereditary disease manifested by multiple small bowel ulcers with nonspecific pathological findings. Recent research has established CEAS as an autosomal recessive disorder caused by mutations in the SLCO2A1 gene, which encodes a prostaglandin transporter. Lately, CEAS has been revealed as “the prostaglandin-associated enteropathy”. Typically, CEAS presents multiple, longitudinal or curved, and shallow ulcers in the ileum but occasionally also presents ulcerative lesions in the stomach and the duodenum. Besides a clinical course and specific gastrointestinal findings, extraintestinal manifestations or a genetic test could facilitate the diagnosis of CEAS.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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