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要旨●活動性大腸結核を有した54例の臨床像,X線造影・内視鏡所見を遡及的に検討した.24例(44%)では明らかな臨床症状を認めなかったが,盲腸(74%)と上行結腸(72%)を中心に,不整形潰瘍(63%),輪状潰瘍(56%),びらん(50%)などの活動性病変が観察された.このうち,80%では腸管変形や回盲弁開大,萎縮瘢痕帯などの所見も併存していたが,軽微な活動性病変のみの症例も11%にみられた.一方,生検標本における結核菌同定は培養法の48%が最も高く,乾酪性肉芽腫は15%で確認されたのみであった.以上より,大腸結核の診断はX線造影・内視鏡検査における所見の拾い上げが中心となるが,軽微な病変のみの症例ではIFN-γ遊離試験を含めた総合的な判断が必要と考えられた.
We investigated the clinicopathological features of 54 patients with colonic tuberculosis. Of these patients, 42(44%)did not manifest any clinical symptoms. Colonic invasion was found mostly in the cecum(75%)and in the ascending colon(74%). The most frequently observed active mucosal lesions in colonoscopy and radiography included irregular ulcers(63%), circular ulcers(56%), and erosions(50%). Although 80% of patients were accompanied by colonic deformity or discolored multiple scars suggesting chronic inflammatory change, mild mucosal lesions were observed in 11% of patients. In the analyses of biopsy specimens, while epithelioid cell granuloma with caseous necrosis was observed only in 15% of patients, the detection rate of acid-fast bacilli was highest in culture(48%). Based on our findings, interferon-gamma release assay may be necessary to diagnose colonic tuberculosis if the disease is suspected in radiography or colonoscopy.
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