Two Cases of Monomorphic Epitheliotropic Intestinal T-cell Lymphoma Shinichi Kawano 1 , Takehiro Torisu 1 , Hiroyuki Kobayashi 2 , Yutaka Nagata 1 , Yuta Fuyuno 1 , Yasuharu Okamoto 1 , Shin Fujioka 1 , Atsushi Hirano 1 , Junji Umeno 1 , Tomohiko Moriyama 1,3 , Yoshifumi Hori 4 , Hidetaka Yamamoto 4 , Minako Fujiwara 5 , Motohiro Esaki 6 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Division of Gastroenterology, Fukuoka Sanno Hospital, Fukuoka, Japan 3International Medical Department, Kyushu University Hospital, Fukuoka, Japan 4Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 5Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 6Department of Endoscopic Diagnostics and Therapeutics, Saga University Hospital, Saga, Japan Keyword: 小腸原発悪性リンパ腫 , 腸管症関連T細胞リンパ腫 , バルーン内視鏡 pp.543-552
Published Date 2019/4/25
DOI https://doi.org/10.11477/mf.1403201632
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 We present two cases of MEITL(monomorphic epitheliotropic intestinal T-cell lymphoma)with a bulky mass resulting in poor prognosis. Case 1 involved a 60-year-old man who was referred to our institution because of weight loss and abdominal fullness. Small bowel radiography revealed thickened Kerckring folds from the duodenum to upper jejunum. Esophagogastroduodenoscopy showed coarse mucosa in the descending part of the duodenum. Following histopathological confirmation of MEITL, he underwent chemotherapy and autologous stem cell transplantation, but died of intestinal perforation eight months later. Case 2 concerned a 60-year-old woman who was referred to our institution with fever and abdominal pain. Small bowel radiography revealed a huge tumorous lesion with intraluminal aneurysmal dilatation in the upper jejunum, and single-balloon enteroscopy showed a circumferential ulcerative lesion with an auriculate ulcer mound. Emergency surgery was performed because of intestinal perforation. MEITL was histologically diagnosed, and postoperative chemotherapy was initiated ; however, she died of progressive disease after six months.

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