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要旨●全身性エリテマトーデス(SLE)の消化管病変としてループス腸炎と蛋白漏出性胃腸症(PLE)があり,前者は虚血性腸炎型と多発潰瘍型に分類される.虚血性腸炎型は小腸の広範な浮腫を特徴とするのに対し,多発潰瘍型では直腸やS状結腸に打ち抜き状潰瘍が多発し,しばしば穿孔を合併する.PLEのX線造影像および内視鏡所見は軽微であるが,時にびらんや小潰瘍を伴う.一方,SLEの上部消化管病変として,血管炎に起因した胃十二指腸潰瘍の報告もある.これらの消化管病変が初発症状や予後不良因子となることがあるので,本症の消化管病変を熟知することは重要である.
Intestinal lesions in SLE(systemic lupus erythematosus)are classified into protein-losing enteropathy and lupus enteritis, which is subdivided into the ischemic enteritis type and multiple ulcer type. The ischemic enteritis type is characterized by diffuse submucosal edema in the small bowel. In protein-losing enteropathy, endoscopic examination usually reveals minimal abnormalities, although erosions or small ulcers are occasionally observed. The multiple ulcer type is characterized by multiple punched-out ulcers found in the distal colon, and they often cause intestinal perforation. In addition, cases of gastroduodenal ulcer caused by vasculitis have been reported. Intestinal lesions can develop as the initial presentation of SLE and severe complications such as intestinal perforation may occur. Thus, intestinal lesions in SLE should be assessed at the initial diagnosis and during the follow-up.
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