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Spruelike Enteropathy Associated with Olmesartan, Report of a Case Masashi Fukushima 1 , Takahiko Itou 1 , Kazuhiro Matsumoto 1 , Kazuya Hosotani 1 , Tatsunori Minamide 1 , Hiroki Kitamoto 1 , Youhei Taniguchi 1 , Masaya Wada 1 , Naoto Shimeno 1 , Shuko Morita 1 , Satoko Inoue 1 , Hiroshi Tei 1 , Yoshiki Suginoshita 1 , Tetsurou Inokuma 1 , Yukihiro Imai 2 1Department of Gastroenterology, Kobe City Medical Center General Hospital, Kobe, Japan 2Department of Pathology, Kobe City Medical Center General Hospital, Kobe, Japan Keyword: スプルー様腸疾患 , オルメサルタン , ダブルバルーン内視鏡 , セリアック病 pp.497-502
Published Date 2016/4/25
DOI https://doi.org/10.11477/mf.1403200604
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 A woman in her sixties was referred to us because of a 2-month history of watery diarrhea. Esophagogastroduodenoscopy revealed atrophy of the duodenal mucosa and nodular mucosa. Capsule enteroscopy and anterograde double-balloon enteroscopy revealed changes such as villous atrophy and nodular mucosa from the duodenum to the ileum. Pathological examination showed villous atrophy and chronic inflammatory cell infiltration. We suspected celiac disease until we learned that test results for antibodies associated with celiac disease were negative. When the patient disclosed that she had been taking olmesartan for 4.5 years, we suspected spruelike enteropathy associated with olmesartan. We confirmed a diagnosis of spruelike enteropathy associated with enteropathy on the basis of examinations and test findings and institution of a diet containing gluten that did not cause diarrhea. Spruelike enteropathy associated with olmesartan is a relatively new disease concept that is characterized by severe malabsorption. Although spruelike enteropathy associated with olmesartan is rare in Japan, the disease should be considered as a differential diagnosis when severe malabsorption is observed.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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