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Japanese

Collagenous Gastroenterocolitis with Protein-losing Enteropathy Associated with Valsartan, Report of a Case Shuji Kochi 1 , Koichi Kurahara 1 , Yumi Oshiro 2 , Keisuke Kawasaki 1,3 , Akiko Saka 1 , Hiroki Yaita 1 , Maya Tokumoto 1 , Tadahiko Fuchigami 1 , Takayuki Matsumoto 3 1Division of Gastroenterology, Matsuyama Red Cross Hospital, Matsuyama, Japan 2Department of Pathology, Matsuyama Red Cross Hospital, Matsuyama, Japan 3Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan Keyword: collagenous gastroenterocolitis , バルサルタン , スプルー様腸症 , 蛋白漏出性胃腸症 , 内視鏡検査 pp.504-510
Published Date 2016/4/25
DOI https://doi.org/10.11477/mf.1403200605
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 An 88-year-old woman presented at our institution with watery diarrhea and edema of the lower extremities occurring after the initiation of oral valsartan administration. Colonoscopy revealed minimally distorted hypervascularity throughout the colon. Histology of biopsy specimens from the colonic mucosa revealed a thickened subepithelial collagen band and inflammatory infiltrate in the lamina propria. Esophagogastroduodenoscopy revealed granular mucosa of the gastric antrum and multiple, diminutive, and linear scratches along the transverse axis in the gastric body. Balloon-assisted endoscopy revealed multiple erosions in the jejunum and ileum. Histological examination of the multiple biopsies obtained from the stomach, duodenum, jejunum, and ileum revealed a collagen band in the subepithelial layer. Both technetium-99m human serum albumin scintigraphy and alpha-1 antitrypsin clearance test showed findings consistent with protein-losing enteropathy. Based on these findings, we diagnosed the patient as having collagenous gastroenterocolitis with protein-losing enteropathy. The condition may have been associated with the use of valsartan.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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