Enteropathy-Associated T-cell Lymphoma Followed-up Using Double Balloon Enteroscopy, Report of a Case Masashi Fukushima 1 , Chiharu Kawanami 2 , Kazuya Hosotani 1 , Tatsunori Minamide 1 , Hiroki Kitamoto 1 , Satoshi Ogawa 1 , Kenji Takashima 1 , Masaya Wada 1 , Naoto Shimeno 1 , Satoko Inoue 1 , Hiroshi Tei 1 , Mikio Fujita 1 , Yoshiki Suginoshita 1 , Akihiko Okada 1 , Tetsurou Inokuma 1 , Yukihiro Imai 3 1Department of Gastroenterology, Kobe City Medical Center General Hospital, Kobe, Japan 2Department of Gastroenterology, Otsu Red Cross Hospital, Otsu, Japan 3Department of Pathology, Kobe City Medical Center General Hospital, Kobe, Japan Keyword: enteropathy-associated T-cell lymphoma , ダブルバルーン内視鏡 , 小腸T細胞リンパ腫 pp.1326-1332
Published Date 2014/8/25
DOI https://doi.org/10.11477/mf.1403114250
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 A male in his sixties was admitted to a local hospital because of severe diarrhea. Abdominal CT(computed tomography)scan showed wall thickenings throughout the small intestine ; the patient was referred to our hospital for further investigations.

 Capsule endoscopy revealed several changes, including fine granular mucosa, erosions, and ulcers. Retrograde DBE(double-balloon enteroscopy)showed similar changes. Based on the findings of pathological examination, immunophenotyping by flow cytometry, and T-cell receptor gene rearrangement, EATL(enteropathy-associated T-cell lymphoma)was diagnosed.

 Retrograde DBE performed again after chemotherapy revealed diffuse fine granular changes with no ulceration in the ileum. Histological examination revealed a residual tumor. Although chemotherapy was continued, the patient died of lymphoma 13 months after diagnosis.

 EATL is a primary gastrointestinal T-cell lymphoma with poor prognosis, and reports of endoscopic findings of EATL are rare. DBE is effective for diagnosis, assessment, and observation of EATL.

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