手掌の皮膚腫瘤で初発した未分化大細胞リンパ腫

・左手掌の皮膚腫瘤より診断した未分化大細胞リンパ腫（anaplastic large cell lymphoma：ALCL）を経験した． ・左腋窩リンパ節にPET/CTでの異常集積を認めたが，リンパ節生検では腫瘍細胞を検出しなかった． ・多剤化学療法は奏効したが再発し，ブレンツキシマブ ベドチン13コース投与後，現在はフォロデシン内服を行っている．全身多発性の皮膚病変が軽快，増悪を繰り返している． （「症例のポイント」より）

A case of primary cutaneous anaplastic large cell lymphoma presenting as tumor of the palm Matsuo, Atsuko1）Nakahara, Satoshi1）Maruo, Keishi1）Jhono, Masayoshi1）Fujimoto, Tetsuhiro2）Suzushima, Hitoshi2） 1）Department of Dermatology, Kumamoto Shinto General Hospital 2）Department of Hematology, Kumamoto Shinto General Hospital Abstract We describe a 56-year-old man presenting with a rapidly developing large ulcerated tumor on his left palm. He also had a high fever and swelling of the left axillary lymph nodes. A diagnosis of anaplastic large cell lymphoma (ALCL)was made via biopsy of a skin lesion. After initiation of systemic chemotherapy, there was almost complete improvement of the skin lesion and lymph nodes. However, after three cycles, the tumor relapsed, and multiple new lesions appeared on his trunk and extremities. These lesions continued to remit and relapse under 13 courses of brentuximab vedotin monotherapy.