両側大腿の浸潤性紅斑を呈した血管内大細胞型B細胞リンパ腫（IVL）

・皮膚病変を伴う血管内大細胞型B細胞リンパ腫（intravascular large B-cell lymphoma：IVL）を経験した． ・紅斑部の皮膚生検で、血管内に充満する腫瘍細胞を認めた． ・リツキシマブ＋CHOP療法が著効した． （「症例のポイント」より）

A case of intravascular large B-cell lymphoma with indurated erythema on the bilateral thigh Yonekura, Kentaro1）Kawakami, Nobuyo1）Takeda, Koichiro1）Kanzaki, Tamotsu1） 1）Department of Dermatology, Imamura General Hospital Abstract We report a 59-year-old woman presenting livedo-like erythema on the bilateral thigh. Her serum lactic dehydro- genase was 900 IU/l, and soluble interleukin-2 receptor was 3253 U/ml. There was nether lymphadenopathy nor central nervous system lesion. Histopathological findings showed large abnormal lymphocytes in dermal and subcutaneous blood vessels. Immunohistochemically these tumor cells were positive for CD 20. A diagnosis of intravascular large B-cell lymphoma ‘cutaneous variant’ was made and we treated the patient with CHOP combined with rituximab.