びまん性大細胞型B細胞リンパ腫患者に生じたhistiocytoid Sweet’s syndrome

・びまん性大細胞型B細胞リンパ腫の治療中に，両手背に自覚症状の乏しい隆起性紅斑局面が出現した．・生検組織で，真皮上層に著明な浮腫と真皮浅層から中層に斑状の組織球様単核球浸潤を認めた．・発熱や関節痛などの全身症状を欠き，ステロイド外用にて皮疹は速やかに消褪した．（「症例のポイント」より）

A case of histiocytoid Sweet’s syndrome with diffuse large B cell lymphoma Hiraiwa, Tomoko1）Yamamoto, Toshiyuki1） 1）Department of Dermatology, Fukushima Medical University Abstract A 68-year-old male with diffuse large B cell lymphoma developed erythematous plaques on his dorsal surface of the hands. He did not have either fever or arthralgia. Histopathological examination from erythema revealed infiltration of histiocytoid mononuclear cells and edema of the upper dermis. The histiocytoid cells were positive for CD4, CD163, CD68 and myeloperoxidase, confirming their macrophage/monocytic lineage. Based on these clinical and histopathological findings, we diagnosed this case as histiocytoid Sweet’s syndrome. The erythema was resolved in a week by topical corticosteroid therapy.