再び進行性壞疸性鼻炎に就て—附Badon使用例

　本疾患は1917年S. Kaufmanにより初めて報告せられてより，既に歐米及び我國に於ても數多く發表されているが，未だに一定の名稱もなく，且つ又其の原因も數多くの諸説はあれどこれと言う定説なく，豫後は頗る不良にして，其の治癒例は柴田，吉田，立木，土佐林　橋本，永井，中川金澤，深町諸氏の報告せる數例にすぎない。私も曾て昭和24年（耳咽第21巻4號）に1治癒例を報告したが，其の原因についての探究は失敗に終つた。此の度偶々かかる症例に再び遭遇し，はからずも其の原因の一端を窺うを得，且つ又再び幸運にも治癒せしめ得たので此所に報告し，諸賢の御參考に供する次第である。

　HOMMA finds malignant tumor cells in the mucous membrane of the nose obtained by biopsy from a patient, a woman aged 31, suffering from progressive gangrenous rhinitis which was marked by high inflammatory process and formation of granulation tissues. These malignant cells are described to be irregular in Shape and size, some avoid and others angular i contour, to be readily stained by hematoxylin but, particularly, noted by the number that were degenerated. Among them are noted the presence of giant cells containing several nuclii with many of these undergoing destruction by showing unorganized nuclear material disemminated within the cell Membrane. That these cells readily disintergrated is shown by presence of liberated nuclear material which was found in considerable amount in the necrotic tissue. Macroscopically the disease is noted by showing a sharp line of demarcation existing between the pathological and the normal tissues; osseous nvolvement is surprisingly small.