慢性副鼻腔炎の起炎菌より作れるアウトワクチン皮内反應に就いて

　Pirquetが1906年に結核感染者と未感染者とでは，ツベルクリンに對する反應が相異し，又種痘を受けた者と受けない者は，痘苗に對する反應が相異する生物學的現象から「變化した反應能力」に對し，アレルギーなる言葉を提唱して以來，今日まで總ゆる分野に，アレルギーの研究は大なる進歩を見た。

　扨慢性副鼻腔炎は遺傳的素因及び體質的素因を疑わせるし種々の療法を施しても容易に治癒せず該疾患の成立，經過，治療に未だ解明し得ない所が少くない。此處に於て慢性副鼻腔炎をアレルギーの立場から解決せんと數多の研究がHansel，Eliss，Proetz，等の人々によつて爲されて來た。アレルギーが理解されている如く，抗原抗體反應によるものとすれば，慢性副鼻腔炎とアレルギーの關係に於て，抗原として細菌を考え得る。即ち細菌性アレルギーが該疾患に認められ得るとの考えから，副鼻腔粘膜の病理學的検査，ヒスタミン皮内反應，鼻汁及び血液中の好酸球數，凝集反應，等を參考にしての，Hansel分類の3型に分け，アウトワクチン皮内反應を行い其成績を發表する次第である。

　TAKEDA in an attempt to solve the question whether or not bacterial contents found in sinusitis are capable of establishing allergen, subjected 30 cases of known sinusitis with skin tests by using autovaccine intracutaneously. The test showed strongly positive dermal reaction in 10 cases, weakly positive in 11 and negative in 9. By means of microscopic examination of sinous mucous membranes, the character of nasal discharge, eosin: hile count, intracutaneous histamine test and cell agglutination, these cases were further classified categorically into three types of affections which according to Hansel is that of truly allergic, purulent and mixed. It was found that all 6 cases of allergic type to be weakly positive; in the purulent type, 10 cases out of 17 to be strongly positive while th other 3 were weakly positive; in the mixed type, 5 cases out of 7 were negative. Presence of bacterial allergy in allergic and purulent types of sinusitis was not recognized but in the mixed type it was shown in majority of cases. Etiologically the mixed type is believed to be the product of bacterial invasion on allergic sinusitis or the result of chronicity in the state of infection whereby offending organisms come to develop allergens to the host; majority of sinusitis of the mixed type are believed to be belonging to this latter category. No special characteriatics were noted in the examination of bacteria of this type.