惡性ヂフテリーの實驗的研究

　緒言

　惡性ヂフテリーは咽頭のフレグモーネ樣變化と，組織の高度な壊疽性變化等に急速な中毒症状を伴ひ，治療血清の無効な事及死亡率の高度な事等によつて，一般のヂフテリーとは劃然と區別されて居る事は衆知の通りである．併し，從來其の原因については定説がなく，今まで擧げられて居る主な説には次の樣なものがある．

　1．ヂフテリー菌と他の細菌殊に溶血性連鎖状球菌との混合感染に由るとするもの．（Finkelstein, Konigsberger, Updype, Frobischer）

　KONNO and SHIOYA attempted to seek the true features of malignant diphteria which causes bodily reactions in the phenomenon of anaphylaxis towards living organisms and performed the following experiments.

　Experimental animals were first immunized against diphtheria with a vaccine prepared by diptheria orgaisms obtained from a malignant case and thereafer drown. Three weeks after this immunization procedure animals were given 1 mg of livi g diphtheria bacilli suspension in the peritoneal cavity by injection. As a result phlegmons were produced on the abdominal wall the features of which were characterized to be much in common with those that would be produced by malignant diphtheria. When injecting agents were substituted by other bacteria in stock cultures or diphtheria toxins such reactions were not seen.

　From considerations of these facts, authors conclude that they are inclined to believe that the underlying pathological cause of malignant diphtheria to be anaphylaxis towards living bacterial organisms.