虚血性脳血管病変に対する高気圧酸素療法の意義—その有効性と限界

Significance of Oxygenation at High Pressure (OHP) as a Therapeutic Method for Occlusive Cerebrovascular Disease

I．はじめに

　近年，虚血性脳血管障害の病態，治療の研究が，脳循環，脳代謝の研究発展と相まって盛んになりつつある^{1,3,8,9,14）}．著者らも，本症の病態，治療に常日頃関心をもち検討をすすめてきた^8,11-13）．

　本症の内科的（保存的）治療中，近年注目されている治療法の1つとして，高気圧酸素療法（以下OHPと略す）がある．本治療が注目される理由は，患者の神経症状を安全に治療しうるという点^2,7,10,11）と，虚血に陥った中枢神経系に対する高気圧酸素下の効果を通して，虚血脳組織の可逆性を知る手がかりになるという^4,6）両面が無理なく両立しうる点にあろう．

Oxygenation at high pressure (OHP) is said to beone ofthe hopeful treatment for restoration of ischemicbrains,caused by occlusive cerebrovascular disease.However,factors contributing to preferable outcome followingOHPhas not been sufficiently clarified so far.

Therefore, this study was undertaken to find outthe factorsrelated to good outcome following OHP by reviewing22cases with occlusive cerebrovascular disease whoweretreated by OHP.

Average age of subjects was 48 years andneurologicalstatus of 22 subjects was classified as severe in11, moderatein 8 and slight in 3.