Behçet病による続発緑内障に対しインフリキシマブ導入後に線維柱帯切除術を施行した3症例

Trabeculectomy for secondary glaucoma in three cases of Behçet disease following systemic infliximab

要約　目的：Behçet病に続発した緑内障に対し，線維柱帯切除術を行った3症例の報告。症例：症例はいずれも男性で，年齢は30，39，44歳である。Behçet病の罹患歴はそれぞれ14か月，8年，14年で，眼圧上昇はいずれも片眼性であった。インフリキシマブをそれぞれ3か月，30か月，2週間全身投与した後に，マイトマイシンCを併用する線維柱帯切除術を行った。結果：罹患眼の術前の眼圧は，それぞれ42mmHg，27mmHg，35mmHgであり，術4年後の現在まで，すべて14mmHg以下に維持されている。重篤な眼炎症発作や感染などの合併症はない。結論：Behçet病3例3眼の緑内障に対し，インフリキシマブ導入後に線維柱帯切除術を行い，良好な結果を得た。

Abstract.　Purpose：To report the outcome of trabeculectomy for glaucoma in 3 cases of Behçet disease. Cases：All were males and were aged 30, 39 and 44 years respectively. Behçet disease had been diagnosed 14 months, 8 years and 14 years before. Ocular hypertension was present unilaterally in all the cases. Trabeculectomy with adjunct use of mitomycin C was performed after systemic infliximab for 3 months, 30 months, and 2 weeks respectively. Results：Intraocular pressure（IOP）in the affected eye was 42 mmHg, 27 mmHg and 35 mmHg respectively. IOP decreased after surgery and has been maintained under 14 mmHg for 4 years until present. There has been no recurrence of intraocular inflammation nor infection. Conclusion：Trabeculectomy was effective in 3 eyes of Behçet disease after introduction of systemic infliximab therapy.