雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

Brain and Nerve No to Shinkei Volume 33, Issue 6 （June 1981）

Brain and Nerve 脳と神経 33巻6号（1981年6月発行）

Japanese English

原著

Subclinical pituitary microadenoma SUBCLINICAL PITUITARY MICROADENOMA 寺本明 ¹ , 田村晃 ¹ , 堀智勝 ¹ , 佐野圭司 ¹ , 平川公義 ² , 長村義之 ³ , 渡辺慶一 ³ Akira Teramoto ¹ , Akira Tamura ¹ , Tomokatsu Hori ¹ , Keiji Sano ¹ , Kimiyoshi Hirakawa ² , Yoshiyuki Osamura ³ , Keiichi Watanabe ³ ¹東京大学脳神経外科 ²京都府立医科大学脳神経外科 ³東海大学病理 ¹Department of Neurosurgery, University of Tokyo Hospital. ²Department of Neurosurgery, Kyoto Prefectural University of Medicine. ³Department of Pathology, Tokai University. pp.625-632

発行日 1981年6月1日 Published Date 1981/6/1

DOI https://doi.org/10.11477/mf.1406204781

PDF(9690KB)

有料閲覧

閲覧方法のご案内

この論文を閲覧するためにはログインが必要になります。

パスワードを忘れた場合新しくユーザー登録する施設共通IDをご利用の方はこちらから

PPV購入案内

1,320円 (1,200円+税10%) こちらは、625ページから632ページの文献です。

PPV（ペイ・パー・ビュー）とは、論文（記事）単位で購入・閲覧ができるサービスです。
購入には医書.jp本会員登録が必要です。

新規会員登録はこちらから

会員登録完了後に改めて上記「購入サイトへ」を選択してください。
または「購入サイトへ」選択後に「購入ログイン」、「新規会員登録」の順に進んでください。

会員登録について詳しくは

こちら

をご確認ください。

Abstract 文献概要
1ページ目 Look Inside

1．緒言

　近年，下垂体前葉ホルモンのRadioirnmunoassayの確立に伴い，functioning pituitary microadenoma （ホルモン産生下垂体微小腺腫）という新しい臨床概念が生まれ，目下，症例数は増加の一途をたどりつつある。

　これらは，従来の臨床的な下垂体腺腫の初期段階であろうと推定されているが，必ずしもすべてのmicroade—nomaが，macroadenoma （microadenomaに対して仮にこう呼ぶ）に成長することには疑問があるとされる^8）。

In order to investigate the incidence and his-tological features of subclinical pituitary micro-adenomas, one thousand pituitary glands obtained from necropsies were studied (Fig. 1). Most of death resulted from acute diseases or accidents; i. e. cardi-ac failure (388), accidents (220), cerebrovascular disease (138), pneumonia (93), gastroenteric disease (71) and other causes (90).

The pituitaries were fixed in 10% buffered forma-lin and then cut in the horizontal or frontal planes, producing three pieces. They were embedded in the paraffin, sectioned and stained with Hematoxi-lin and Eosin in the usual way.

Fifty-eight pituitary glands (5.8%) were found to contain discrete microadenomas varying in size from 0.5 to 5.5mm in diameter. The frequency of them was significantly high in the fifth and eighth decades, while the incidence in both sexes was almost equal (Fig. 2 and Table 1). The sizes of subclinical microadenomas tended to increase with advancing age, except for some large ones found in the fifth decade (Fig. 3). Forty-four cases of them (76%) were localized in the lateral wing and the others were found near or in the mucoid wedge (Fig. 4 & 5).

With H-E stain, they were classified into 55 chromophobe and three eosinophilic adenomas.

In an attempt to identify the endocrinological functions of these adenomas, 30 cases were studied by peroxidase-labeled antibody methods using anti-bodies against human PRL, GH, ACTH, TSH, FSH and LH (Fig. 6 & 7).

With immunostains, they were devided into 9 PRL producing, two GH producing and 19 non-functioning adenomas. PRL adenomas were pre-dominantly localized in the anterolateral portion of the pituitary gland, while GH adenomas were seen more medially (Fig. 5).

Since immunohistochemical findings of these functioning adenomas were in accordance with those of clinical adenomas, it was supposed that some subclinical microadenomas could develop into clinical tumors.