総合呼吸機能自動解析システムを使用した呼吸機能検査測定値の標準値および予測式—成人の肺気量分画，肺換気機能，肺拡散能について

Standard values and prediction equations for respiratory function measurements:Lung volume, ventilatory function and pulmonary diffusion in healthy adults

　近年，大気汚染や喫煙その他の原因で呼吸機能障害が急増し，それに伴って呼吸機能検査の需要が著しく高まっている。呼吸機能検査は呼吸機能障害の発見，障害の程度および治療に役立つのみならず，多くの疾患の補助診断，治療経過，術前検査および予備能力などの判定や，大気汚染・公害病に対する診断と予防などにも欠くことのできない検査法の1つとなり，臨床上重要な位置を占めている。

　呼吸機能検査測定値の評価には標準値を用いて判定する必要があるが，わが国では総合的に確立された標準値は少なく，諸外国の報告を基準に標準値を定めている検査機関が多いのが現状である。しかし，人種，体格，生活環境および検査に用いる機械の原理の相違などから，これらの値を日本人の呼吸機能検査成績と比較するには問題があり，日本人を対象とした呼吸機能検査標準値を設定する必要性がある。

Standard values and prediction equations of res-piratory function measurement can be greatly alte-red by the difference of the equipments and methods employed as well as race, body characteristics, and living environment of the subjects being studied. It is therefore of necessity to obtain prediction equa-tions which match the up-to-date physical characteri-stics of Japanese. In the present study, pulmonary functions of 1041 healthy adults aged from 20 to 79 were measured with an automated spirometer (FUDAC 80) . The average values and standard de-viations of each measurement separated by sex and grouped by decades were calculated, and the corre-lation of these values and the biological characteri-stic factors (i.e. body weight, height, age) were exa-mined. Prediction equations of each pulmonary me-asurements applicable to both sexes ranged from 20 to 79 year-old were derived by employing a multiple regression analysis method. The measurements in-clude vital capacity, expiratory reserve volume, in-spiratory capacity, functional residual capacity, re-sidual volume, total lung capacity, RV/TLC, for-ced vital capacity, FEV₁, FEV_1%, maximal mid-expiratory flow, maximal voluntary ventilation, CO pulmonary diffusing capacity, and D_LCO/V_A. The prediction equation of these values are statistically highly reliable (p>0.01) , and are considered to be useful in the clinical application.