Regulation of bone remodeling and disease. Bone remodeling and modeling/mini-modeling. Hasegawa Tomoka 1 , Amizuka Norio 2 1Developmental Biology and Hard Tissue, Faculty of Dental Medicine, Hokkaido University,Japan. 2Developmental Biology and Hard Tissue, Faculty of Dental Medicine, Hokkaido University,Japan. pp.1713-1722
Published Date 2017/11/28
DOI https://doi.org/10.20837/4201712039
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 Modeling, adapting structures to loading by changing bone size and shapes, often takes place in bone of the fetal and developmental stages, while bone remodeling-replacement of old bone into new bone-is predominant in the adult stage. Modeling can be divided into macro-modeling(macroscopic modeling)and mini-modeling(microscopic modeling). In the cellular process of mini-modeling, unlike bone remodeling, bone lining cells, i.e., resting flattened osteoblasts covering bone surfaces will become active form of osteoblasts, and then, deposit new bone onto the old bone without mediating osteoclastic bone resorption. Among the drugs for osteoporotic treatment, eldecalcitol(a vitamin D3 analog)and teriparatide(human PTH[1-34])could show mini-modeling based bone formation. Histologically, mature, active form of osteoblasts are localized on the new bone induced by mini-modeling, however, only a few cell layer of preosteoblasts are formed over the newly-formed bone, and accordingly, few osteoclasts are present in the region of mini-modeling. In this review, histological characteristics of bone remodeling and modeling including mini-modeling will be introduced.


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