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New generation treatment of intractable ventricular arrhythmia by extracorporeal radiation therapy Mari Amino 1,2 1Department of Cardiology Tokai University School of Medicine Keyword: 体幹部定位放射線治療 , 致死性心室不整脈 , 低侵襲性治療 pp.757-765
Published Date 2021/8/10
DOI https://doi.org/10.18888/rp.0000001673
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The recent expansion of advanced heart failure therapies has altered the patient’s prognosis with ventricular arrhythmias. The radiofrequency catheter ablation remains a mainstay treatment for refractory ventricular tachycardia(VT), but the results with this approach among the advanced heart failure population are less than optimal. Stereotactic body radiotherapy(SBRT)has recently been applied in the field of arrhythmia management. It has been most widely assessed in the VT treatment but may also have potential in the control of atrial fibrillation(AF). It is often termed cardiac stereotactic ablative radiotherapy(SABR)as well. This low invasive approach has shown great promise clinically, and multiple groups have demonstrated the safety and efficacy for the refractory VT. However, little is known about the electrophysiological properties of radiation on non-neoplastic tissue such as the myocardium. We introduce the results of non-invasive parameters evaluated by ambulatory ECG in the clinical case report before and after irradiation and the pre-clinical data pertaining to the use of carbon ion in cardiac tissue.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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