Coronary CT derived instantaneous wave-free ratio(CT-iFR)for detection of myocardial ischemia Michinobu Nagao 1 1Department of Diagnostic Imaging & Nuclear Medicine Tokyo Women’s Medical University Keyword: 冠動脈CT血管造影法(coronary CT angiography) , 瞬時血流予備能比(instantaneous wave-free ratio:iFR) , coronary plaque , 心筋虚血 pp.1307-1315
Published Date 2020/11/10
DOI https://doi.org/10.18888/rp.0000001436
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We develop an instantaneous wave-free ratio(CT-iFR)derived from dynamic coronary CT angiography combined low dose and boost scan. The present study investigates burdens of high-risk plaque on coronary circulation using CT-iFR and the diagnostic performance for detection of myocardial ischemia. CT-iFR for arteries with high-risk plaque was significantly lower than those for arteries with calcified plaque and non-plaque(0.71±0.17 vs. 0.94±0.20 vs. 0.93±0.21). CT-iFR for territories with ischemia was significantly smaller than those without(0.68±0.15 vs. 0.89±0.17). ROC analysis revealed the optimal cutoff of CT-iFR 0.73 for detecting myocardial ischemia with AUC of 0.88, a sensitivity of 56%, and a specificity of 99%. CT-iFR is associated with plaque characteristics, and is a non-invasive technique for detection of myocardial ischemia.

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