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Detection of papillary muscle ischemia using high-resolution cine imaging of ammonia PET Michinobu Nagao 1 1Department of Diagnositic Imaging & Nuclear Medicine Tokyo Women’s Medical University Keyword: papillary muscle ischemia , アンモニアPET , time of flight , 心筋血流予備能 pp.9-16
Published Date 2020/1/10
DOI https://doi.org/10.18888/rp.0000001104
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Myocardial papillary muscle(PM)plays an important role in cardiac contractility. PM arises from end-myocardium and is located most distant site under coronary circulation. Thus, PM can be foremost area at risk of myocardial ischemia in coronary artery disease. However, it is difficult to detect PM ischemia by myocardial perfusion SPECT due to the limited spatial resolution. Recent technological development and improved spatial resolution enables the detection of endocardial ischemia using high-resolution time of flight PET. We propose the detection method of PM ischemia using high-resolution cine imaging of ammonia PET, and investigate the association with PM ischemia and myocardial flow reserve(MFR). Our results show that PM ischemia was seen in 15 of 47 patients with coronary artery disease(32%), and that global MFR was significantly lower for patients with PM ischemia than those without. In conclusion, high-resolution cine imaging derived from ammonia PET enables detection of PM ischemia in about 30% of patients with coronary artery disease. PM ischemia associates with reduced global-MFR, suggesting that it is an important sign of early ischemia confined to the papillary muscle or the microvascular injury.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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