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Japanese

Development of radiolabeled compounds for radiotheranostics Kazuma Ogawa 1 1Institute for Frontier Science Initiative Kanazawa University Keyword: radiotheranostics , 核医学治療 , アスタチン-211(211At) pp.991-999
Published Date 2020/8/10
DOI https://doi.org/10.18888/rp.0000001355
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“Theranostics” is a portmanteau word made by combining “therapeutics” and “diagnostics,” and it must be useful for the personalized medicine concept. Recently, the word, “radiotheranostics,” has also been used. It means theranostics using radioisotopes, which are for imaging and therapy. For radiotheranostics, a diagnostic radiolabeled compound and a corresponding therapeutic radiolabeled compound can be prepared by introducing diagnostic and therapeutic radioisotopes into the same position in the same precursor. These diagnostic and therapeutic radiolabeled compounds are expected to show similar pharmacokinetics, which is vital for radiotheranostics. Diagnostic imaging in radiotheranostics can predict the absorbed radiation dose in each organ for therapy. Thus, the therapeutic and side effects could be calculated. In this manuscript, I describe the development of radiohalogenated compounds targeting sigma-1 receptor and αVβ3 integrin for radiotheranostics.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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