INTENSIVIST Volume 11, Issue 1 (January 2019)

Pharmacokinetics of antimicrobial agents for the treatment of critically ill patients Kenichi NAKAZONO 1 1Department of Pharmacy St. Marianna University School of Medicine Yokohama City Seibu Hospital pp.199-213
Published Date 2019/1/1
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Treating infections is one of the most important elements of critical care. Avoiding a delay in initiating antimicrobial therapy is of the utmost importance. The optimal dosing of antimicrobial agents and avoiding sub-therapeutic concentrations are just as important. Pharmacokinetic parameters of antimicrobial agents in the treatment of critically ill patients are influenced by multiple factors, including fluid resuscitation, the presence of multiple organ dysfunction and/or comorbidities. Measurement of serum concentrations is not routinely available for all antimicrobial agents. Therefore, optimal dosing should be guided by pathophysiology and the patient's individual physiologic status. This review article describes pharmacokinetics considerations in critically ill patients and the process for an individualized optimal antimicrobial dosing strategy.

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11巻1号 (2019年1月)
電子版ISSN 2186-7852 印刷版ISSN 1883-4833 メディカル・サイエンス・インターナショナル