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Autoimmune pancreatitis Kazuichi Okazaki 1 , Atsushi Nakajima 1 , Masanobu Kishimoto 1 , Akiko Kurishima 1 , Kazushige Uchida 1 1Division Of Hepatology And Gastroenterology Kansai Medical University Keyword: 自己免疫性膵炎 , IgG4 , IgG4関連疾患 pp.753-761
Published Date 2011/8/15
DOI https://doi.org/10.11477/mf.1542102695
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Recent studies have suggested the existence of two subtypes of autoimmune pancreatitis (AIP) : type 1 AIP, related to IgG4 (lymphoplasmacytic sclerosing pancreatitis) ; and type 2 AIP, related to a granulocytic epithelial lesion (idiopathic duct-centric chronic pancreatitis). Compared with type 2 AIP, the clinicopathological features of type 1 AIP, with increased serum IgG4 levels, abundant infiltration of IgG4+plasmacytes and lymphocytes, autoantibodies, and steroid responsiveness, are more suggestive of abnormal immunity such as autoimmunity. Moreover, patients with type 1 AIP often have extrapancreatic lesions, such as sclerosing cholangitis, sclerosing sialadenitis, or retroperitoneal fibrosis, showing pathological features similar to those of the pancreatic lesions. Based on these findings, an international concept of and diagnostic criteria for AIP have been proposed recently.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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