嗅神経芽腫の2症例ならびに文献的考察

OLFACTORY NEUROBLASTONIA: REPORT OF TWO CASES

　I．はじめに

　鼻腔内嗅粘膜上皮より発生するとされている嗅神経芽腫は，非常に稀な腫瘍である。筆者らが内外文献を渉猟した限りでは，1924年にBerger^1）が報告して以来，現在まで188例を数えており，このうち本邦では1964年，三輪ら^2）の報告以来11例を数えるのみである。当教室では，最近，本腫瘍の2症例を経験したので，報告するとともに，この2例を加えた190例に対して，若干の文献的考察ならびに，統計的観察を行った。また，2例のうち1例は，ヌードマウス移植継代に成功しており，これについてもあわせて報告する。

　Olfactory neuroblastoma is a rare, mlignant tumor, arising from the olfactory mucosa.

　The purpose of this paper is to report our cases in addition to 188 cases reported in the literature and to report the successful and first trial of transplantation of olfactory neuroblastoma to nude mice.

　Case 1 A 68-year-old man developed bilateral nasal obstruction and a mass in the nasal cavity was found. Biopsy of the nasal mass revealed olfactory neuroblastoma.

　A complete remission was obtained with radio-therapy. There is no evidence of recurrence of tumor for more than four years after completion of irradiation.

　Case 2 A 68-year-old man with episodes of epistaxis was diagnosed as having malignant tumor of the nose. He was treated with preoperative irradiation followed by surgery, but he died two years after the first treatment.

　Pathological investigation revealed olfactory neuroblastoma. Transplantation of tumor tissue into mude mice was successful.

　It is our conclusion that combined therapy with preoperative irradiation followed by resection of tumor with radical neck dissection is the most suitable treatment for this lesion.