喉頭・頬粘膜および舌・下咽頭重複癌の2例

MULTIPLE CARCINOMA INVOLVING THE CHEEK, TONGUE, LARYNX, AND HYPOPHARYNX, A REPORT OF TWO CASES

　I．はじめに

　近年，重複悪性腫瘍（多発性原発性悪性腫瘍）については，基礎，臨床の各方面においてその統計的観察をはじめとして悪性腫瘍の発生機序の究明の手がかりにもなり得る報告がなされている。

　現今の悪性腫瘍における診断および治療の進歩，悪性腫瘍が増加しているという事実，さらに腫瘍免疫学の発展などとともに重複悪性腫瘍は，今後も検討されるべき多くの重要な問題を含んでいる。

　Observations are made on 2 rare cases of multiple carcinoma involving the cheek-larynx and tongue-hypopharynx along with 23 other similar cases acquired at the ENT Department of the Keio University Medical School during the period of 18 years. To this list were added 222 cases of similar nature reported in the literature of this country.

　Case 1. The patient, at the age 71, developed a laryngeal cancer for which total laryngectomy was performed. He remained well until the age 77 when he developed a malar cancer. The patient was treated by intravenous administration of BLM and Linac irradiation which macroscopically eliminated the lesion. He is presently under observation with the administration of OK-432.

　Case 2. The patient, at the age 62, was treated for lingual cancer, but, the following year she developed pharyngeal cancer. The patient is now afiring well following surgical intervention and administration of intravenous BLM and Linac irradiation.