Fibrous Dysplasiaより悪性化したと思われる上顎骨肉腫の一例

MAXILLARY SARCOMA THAT APPEARED TO HAVE TURNED MALIGNANT FROM FIBROUS DYSPLASIA

　Ⅰ．緒言

　Fibrous dysplasiaが悪性化して肉腫を発生したという報告は非常に少なく，著者が外国および本邦の文献を渉猟し得た範囲においては，38例を数えるにすぎず，このうち，頭部顔面領域に発生したものは19例にすぎない。われわれの症例は，10歳の時に左上顎のfibrous dysplasiaの診断の下に手術を受け，さらに再発予防の目的でラドン・シードの刺入を受け，その後経過良好であつたが，15年後に左上顎のosteogenic sarcomaの発生をみた稀有なる一例である。

　A case of fibrous dysplasia that later resulted in an osteogenic sarcoma is reported. A fibrous dysplasia of the left maxilla was recognized when the patient was at the age of 10. Fifteen years later this lesion was found to be changed into an osteogenic sarcoma. The authors made review of literature on the report of similar cases and come to the following conclusions:

　1. There is a tendency in which the fibrous dysplasia may become malignant when exposed to irradiation treatments. Therefore, the treatment of these cases should be limited to surgery.

　2. Fibrous dysplasia and other osteogenic malignancies are reluctant in response to either irradiation treatment or chemotherapy; they should he treated by surgery.