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Ⅰ.まえがき
酵素剤が臨床治療面に使用されてから既にかなりの年月を経てきたが,近年酵素化学の進歩とともに種々の酵素が発見されて,その作用が明らかになるとともに治療面においても脚光をあびるようになつてきた。とりわけ蛋白分解酵素は耳鼻咽喉科領域においても注目するところとなり,一部蛋白分解酵素の局所使用を主として,最近では非経口投与による全身療法にもみるべき効果のあることが報告されつつある。
我々は今回新たに創製されたEmpynase(蛋白分解酵素Pronase-Pancreatin)を用いて耳鼻咽喉領域疾患特に慢性副鼻腔炎に対して,従来の局所使用または非経口的全身適用と異つた経口投与による全身適用によつて治療を試みた。Empynaseは単独にまたは抗生物質と併用して,内服のみで,あるいは副鼻腔炎根治手術の術前,術後に投与したところ著明な効果を認めたので報告する。
An attempt was made in employing Empynase an agent causing protein catabolism by internal administration for treatment of chronic paranasal sinusitis. The method of administration was divided into different groups, those in whom the agent was given by mouth alone, in whom it was given preoperatively and in whom it was given postoperatively.
When Empynase was administered by mouth alone favorable results were seen in 65.7% of cases; improvement of symptoms became obvious it 1 to 2 weeks of its administration.
By preoperation 40% of cases became free of pus discharge from the paranasal sinuses.
In postoperative administrations 63.3% of cases showed a marked improvement of nasal symptoms. This improvement was similar to the results attained by postoperative use of antibiotics.
No untoward side-efects are noted by use of Empynase.
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