耳性化膿性髓膜炎に於けるオーレオマイシン試用治験例

　緒言

　ペの発現以来耳性化膿性髓膜炎の治癒率は夫以前に比し向上した事は事実だが未だ甚だしく隔靴掻痒の感が深い．其拠つて来る所以は，全身的投与では髓液内への移行が不充分であり，髓腔内注入では副作用が強く，グラム陰性菌には奏効しないという3点に要約する事が出来る，オヽマは経口投与で充分な有効濃度の髓液内移行が可能だとせられ且つグラム陰性菌にも奏効するとせられるから，理論上は優秀な治療剤と考えられる．そこで私はペがどうしても奏効しなかつた耳性化膿性髄膜炎にオ・マを試用したところ，幸い治癒した1例を得たので其の概要を報告する．

MINOWADA performed zaufal'a operation on a boy 14 years old who was affected for 2 years with chronic purulent otitis roctlia,of the right ear. Seve, en days following this procedore the patient develo-ped meningitis and for this reason the ,petrous pyra-mid was opened after Unterberger's method. The patient was given penicillin injections, for the peri-od of 40 days thereafter, that amounted to 4,500,000 units by intramuscular route, 1,940,000 units by in-travenous and 350,000 units intraspinally. When, in spite of this treatment the patient showed no impro-vement, aureomycin therapy was started consisting of intravenous route at first which was soon followed with dosage by mouth. The results of this latter therapy were markedly effective; the spinal fluid becoming relatively clear on the 4 th day of treatm-ent; the patient becoming completely recovered on the 20 th day. The total amount of aureomycin us-ed was 13.9 gm.