髄膜腫，神経鞘腫の成長解析について—Ki−67 PAP染色

Cell Kinetics of Human Meningiomas and Neurinomas: Ki-67 PAP stain

I．はじめに

　中胚葉起源のmeningiomaおよびneurinomaは基本的には良性腫瘍である．しかし，meningiomaは臨床的にも組織学的にも良性と悪性の境界が画し難いことがあり^12），Simpsonの手術gradeが同じで組織像が普通のそれと何ら変らない症例のなかに急速な再発を示す例がある．

　さらにWHO分類でgrade II-IIIと規定されているhemangiopericytic type^13）の増殖分画は，meningiomaの他の組織型と差があり，gliomaのgrade II-IIIに匹敵するほど大きなものであるか否かが明らかにされていない．

Seventeen surgically resected meningiomas and six neurinomas including one neurofibroma were labelled with frozen sections using a monoclonal antibody Ki-67, which reacts with a nuclear antigen expressed by pro-liferating cells.

In thirteen classic non-malignant meningiomas, the percentage of stained cells ranged from 0.2 to 3.2% (mean, 1.4%). Those of three recurrencies consisted of anaplastic one and another one with anaplastic compo-nent, and one hemangiopericytic type ranged from 2.9 to 8.7% (mean, 4.8%) . Four classic non-malignant neurinomas and one neurofibroma had the range from 0.3 to 2.7% (mean, 1.3%) .