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K1-67 PAP STAIN FOR HISTOLOGIC GRADING OF BRAIN TUMORS BY SQUASH PREPARATIONS Taichiro Shibata 1,4 , Christoph B Ostertag 2 , Benedikt Volk 3 1Department of Neuropathology, Zurich University 2Department of Stereotactic Neurosurgery, Saar University 3Department of Neuropathology, Freiburg University 4Present Address: Department of Neurology and Neuropathology, Jinsei Hospital pp.55-60
Published Date 1989/1/1
DOI https://doi.org/10.11477/mf.1406206240
  • Abstract
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Using Ki-67 monoclonal antibody to the nuclear antigen of proliferating cells, the squash prepa-rations of 141 brain tumors and the 36 frozen sections from corresponding tumor tissues were stained with peroxidase-antiperoxidase method. The staining indices in squash preparations corre-lated well to those in the corresponding frozen sections. There were good correlations between the percentage of stained cells and the histologic grade in agreement with known biologic behavior. In order of decreasing malignancy, the averages of Ki-67 staining indices were 26. 7% for metastatic carcinomas, 12. 6% for glioblastomas, and less than 2. 8% for benign mesodermal tumor groups.

Ki-67 staining with squash preparations could be applied to small tissues obtained by transsphe-noidal surgery and stereotactic surgery as valuable adjuncts to intraoperative histologic diagnosis and the estimation of histologic malignancy.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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