Pathological Study of Toxic Polyneuropathy (Ⅰ): Experimental Formation of Polyneuropathy by Methylmercury Hideyo Matsumoto 1 , Nobue Tomio 1 , Takamasa Kameda 1 1Dept. of Pathology, Kumamoto Univ. School of Med pp.660-669
Published Date 1969/11/25
DOI https://doi.org/10.11477/mf.1431904632
  • Abstract
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 Fifty-one adult and weanling rats have been administered per os with methylmercuric chloride and the resulting pattern of degeneration in peripheral nerves has been studied.

 Methylmercuric chloride can produce disturbance of the peripheral nerves at a dose of 5mg per day, totalling 40-60mg in three weeks.

 Histopathologically, methylmercuric chloride predominantly affects myelin sheath, while axon fibers are less damaged. The pattern of degeneration of myelin sheath is segmental demyelination. These disturbances begin to occur usually in Ranvier's node.

Copyright © 1969, Igaku-Shoin Ltd. All rights reserved.


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