Pathological Studies on Organic Mercury Poisoning: Supplement to Histochemical Demonstration of Mercury in the Brain of Minamata Disease Hideyo Matsumoto 1 , Takamasa Kameda 1 , Tadao Takeuchi 1 1Dept. of Pathology, Kumamoto Univ., School of Medicine pp.270-278
Published Date 1969/6/25
DOI https://doi.org/10.11477/mf.1431906445
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 Mercury in the nerve system of 24 autopsy cases of Minamata disease were examined by histochemical and quantitative techniques.

 In quantitative observations, by use of dithizone method, the mercury content was distributed from 21.3 to 0.1 p.p.m. High content was observed in the acute and subacute cases. The mercury content was reduced gradually in the chronic cases in proportion to the clinical course. In the chronic cases prolonged about ten years a small amount of mercury in the brain still was noticed.

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