Neuropathological Studies on Organic Mercury Intoxication: with Special Reference to Distribution of Mercury Granules Yo Oyake 1 , Masaharu Tanaka 1 , Hiroshi Kubo 1 , Masao chichibu 1 1Department of Neuropathology, Brain Research Institute, Niigata University School of Medicine pp.744-750
Published Date 1966/12/25
DOI https://doi.org/10.11477/mf.1431904370
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Two cases (Case 1: a 19-year-old male wor-ker, with over 40 day's clinical course. Case 2: a 28-year-old male farmer, with 3 months's clinical course) of organic mercury intoxication, occurred in Niigata district in 1965, were histologically and histochemically examined. Histologic findings of the two were very similar to those of Minamata disease, i.e. cortices of calcarine area, transverse temporal and post-central gyri showed marked devastation (neu-ronal loss, astrocytic and microglial prolifera-tion, and spongiose interstice). Devastation of granule cell layer of cerebellum was prominent in case 1, but slight in case 2.

Over 100 small tissue pieces were taken from various sites of brain and cord and impregnated with Timm's method (slightly modified by us) for heavy metals. Developed granules, which were thought to be mostly mercury granules with some reasons, were found mainly in astro-cytes, microglia and adventitial cells and few, if any, neurons. Distribution of granules was plotted in central nervous system (Photo 2 and 3). Heavy deposition occurred in calcarine cortex, transverse temporal and postcentral gyri as well as cerebellar cortex, corresponding so exactly to areas with heavy pathologic changes. This finding may suggest an importan-ce of histotoxic effect of agens, with regard to pathogenesis of organic mercury intoxication.

Copyright © 1966, Igaku-Shoin Ltd. All rights reserved.


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