Japanese
English
- 有料閲覧
- Abstract 文献概要
- 1ページ目 Look Inside
- 参考文献 Reference
florbetapir(18F)は,アルツハイマー型認知症が疑われる認知機能障害を有する患者の脳内アミロイドベータ(Aβ)斑の可視化を目的とした放射性標識化合物である。脳内Aβの蓄積の有無を知ることは,治療方針の決定や検査計画を立てるうえでの臨床における有益性があり,今後アミロイドPETイメージングが診療に用いられることが想定される。本稿では,アミロイドPETイメージングの有用性および臨床的意義を臨床研究のデータをもとに紹介し,日本における適正使用について解説する。
Abstract
florbetapir (18F) is a radiolabeled compound that can be used to visualize amyloid-beta (Aβ) plaques in the brains of patients with cognitive dysfunction, who are suspected of having Alzheimer disease (AD). Knowing the status of Aβ accumulation in the brain is beneficial to selecting therapeutic strategies or to planning of laboratory examinations, hence amyloid PET imaging is expected to be utilized more often in a clinical setting. Based on the results of a clinical study of florbetapir (18F), this review discusses the usefulness and clinical significance of amyloid PET imaging, and its appropriate use in Japan.
(Received Octover 7, 2015; Accepted February 15, 2016; Published October 1, 2016)
Copyright © 2016, Igaku-Shoin Ltd. All rights reserved.