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Clinical Implications and Appropriate Use of Amyloid Imaging with florbetapir (18F) in Diagnosis of Patients with Alzheimer Disease Tomomi Nakamura 1 , Atsushi Iwata 2 , Kaname Ueda 1 , Chihiro Namiki 3 1Eli Lilly Japan 2Department of Neurology, Graduate School of Medicine, The University of Tokyo 3Department of Psychiatry, Graduate School of Medicine, Kyoto University Keyword: アルツハイマー病 , アミロイドイメージング , florbetapir , バイオマーカー , 適正使用 , Alzheimer disease , amyloid imaging , florbetapir , biomarker , appropriate use pp.1215-1222
Published Date 2016/10/1
DOI https://doi.org/10.11477/mf.1416200578
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Abstract

florbetapir (18F) is a radiolabeled compound that can be used to visualize amyloid-beta (Aβ) plaques in the brains of patients with cognitive dysfunction, who are suspected of having Alzheimer disease (AD). Knowing the status of Aβ accumulation in the brain is beneficial to selecting therapeutic strategies or to planning of laboratory examinations, hence amyloid PET imaging is expected to be utilized more often in a clinical setting. Based on the results of a clinical study of florbetapir (18F), this review discusses the usefulness and clinical significance of amyloid PET imaging, and its appropriate use in Japan.

(Received Octover 7, 2015; Accepted February 15, 2016; Published October 1, 2016)


Copyright © 2016, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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