BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 69, Issue 7 (July 2017)

Amyloid Positron Emission Tomography in the Therapeutic Strategies for Alzheimer's Disease Kenji Ishii 1 1Team for Neuroimaging Research, Tokyo Metropolitan Institute of Gerontology Keyword: アミロイドイメージング , ポジトロンエミッション断層撮影 , アルツハイマー病 , 疾患修飾薬 , 予防 , amyloid imaging , positron emission tomography , Alzheimer's disease , disease modifying drug , prevention pp.809-818
Published Date 2017/7/1
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Amyloid positron emission tomography (PET) has been developed as a non-invasive neuroimaging technique that enables us to visualize the accumulation of fibrillar amyloid-beta (Aβ) in the living human brain with histopathological confirmation. As the deposition of fibrillar Aβ is the earliest detectable biomarker of Alzheimer's disease (AD), amyloid PET is useful not only to increase the probability of a correct diagnostic in clinical practice and clinical studies, but also to enrich appropriate participants in the clinical trials of disease modifying drugs for early stage of AD. The amyloid positivity has been shown to be affected by age and APOE ε4 allele presence. In combination with the emerging technique of tau imaging, amyloid PET will reveal details of the early pathophysiological mechanism of AD, which will lead to the development of effective disease modifying therapies and prevention strategies. Amyloid negativity by amyloid PET is the most reliable marker to exclude the possibility of AD in the differential diagnosis of dementia diseases. Therefore, amyloid imaging is also essential for the clinical studies and clinical trials targeting non-AD dementia diseases such as frontotemporal lobar degeneration, argyrophilic grain disease and neurofibrillary tangle dominant disease. Establishing an in vivo imaging technique to visualize tau and alpha synuclein will accelerate further understanding of non-AD dementias.

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BRAIN and NERVE-神経研究の進歩
69巻7号 (2017年7月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院