BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 71, Issue 10 (October 2019)
Japanese

Apolipoprotein E4, a Genetic Risk Factor for Alzheimer's Disease Masataka Kikuchi 1 , Akihiro Nakaya 1 1Department of Genome Informatics, Graduate School of Medicine, Osaka University Keyword: アポリポ蛋白E , 非コーディング領域 , 染色体高次構造 , ポリジェニック効果 , apolipoprotein E , non-coding region , chromatin higer-order structure , polygenic effect pp.1053-1060
Published Date 2019/10/1
DOI https://doi.org/10.11477/mf.1416201404
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Abstract

Apolipoprotein E (APOE) is reported to be a strong genetic risk factor for Alzheimer's disease (AD), broadly contributing to the AD pathologies observed in most populations. However, it is difficult to explicate these AD pathologies based only on the known functions of APOE. In this review article, we revisited the histories and functions of APOE and also reviewed its recently elucidated the pleiotropic roles in the brain.


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基本情報

18816096.71.10.jpg
BRAIN and NERVE-神経研究の進歩
71巻10号 (2019年10月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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