Apolipoprotein E4, a Genetic Risk Factor for Alzheimer's Disease Masataka Kikuchi 1 , Akihiro Nakaya 1 1Department of Genome Informatics, Graduate School of Medicine, Osaka University Keyword: アポリポ蛋白E , 非コーディング領域 , 染色体高次構造 , ポリジェニック効果 , apolipoprotein E , non-coding region , chromatin higer-order structure , polygenic effect pp.1053-1060
Published Date 2019/10/1
DOI https://doi.org/10.11477/mf.1416201404
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Apolipoprotein E (APOE) is reported to be a strong genetic risk factor for Alzheimer's disease (AD), broadly contributing to the AD pathologies observed in most populations. However, it is difficult to explicate these AD pathologies based only on the known functions of APOE. In this review article, we revisited the histories and functions of APOE and also reviewed its recently elucidated the pleiotropic roles in the brain.

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