雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Apolipoprotein E and Alzheimer's disease Makoto Michikawa 1 1Department of Alzheimer's Disease Research, National Institute for Longevity Sciences Keyword: アポリポ蛋白E , コレステロール , 老人斑 , タウ蛋白リン酸化 pp.367-378
Published Date 2005/6/10
DOI https://doi.org/10.11477/mf.1431100054
  • Abstract
  • Look Inside

The possession of apolipoprotein E(apoE)ε4 allele is a major risk factor for Alzheimer's disease(AD). There have been numerous studies to show apoE isoform-specific actions and several hypotheses underlying the association of the apoEε4 allele with AD have been proposed. However, the development of therapeuitical approaches or prevention of AD based on these findings has not been developed, yet. This review article described the differences in structural and biophysical properties of apoE isoform, and their functions under normal and abnormal conditions, which have been proposed to lead AD development. Some of the mechanisms might be targets for the development of AD.


Copyright © 2005, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

関連文献

もっと見る

文献を共有