雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Multifunctional Roles of APOE in Alzheimer's Disease Pathogenesis Takayoshi Tokutake 1 , Kensaku Kasuga 2,3 , Norikazu Hara 2 , Takeshi Ikeuchi 2 1Department of Neurology, Brain Research Institute, Niigata University 2Department of Molecular Genetics, Department of Bioinformatics, Bioresource Science Branch, Center for Bioresources, Brain Reserch Institute, Niigata University 3Center for Transdisciplinary Reserch, Niigata University Keyword: アポリポ蛋白E , アルツハイマー病 , 感受性遺伝子 , プレクリニカル , 先制医療 , apolipoprotein E , Alzheimer's disease , susceptibility gene , preclinical , preventive medicine pp.703-712
Published Date 2016/7/1
DOI https://doi.org/10.11477/mf.1416200498
  • Abstract
  • Look Inside
  • Reference

Abstract

Numerous epidemiological studies have shown that the apolipoprotein E gene (APOE) is a strong genetic risk factor for Alzheimer's disease (AD) among people from various ethnic backgrounds. ApoE occurs as three isoforms that differ at two amino acids residues (112 and 158): ApoE ε2, ε3, and ε4. The ε4 allele is responsible for a genetic predisposition to AD, increasing the risk of AD by approximately 4-fold compared to the common ε3 allele. In contrast, the ε2 allele shows a protective effect against AD. APOE ε4 is known to affect the age at onset of AD in a dose-dependent manner. In addition to the role of genetic risk, increasing evidence suggests that the substantial effects of APOE genotypes on cognitive function, imaging and biomarker findings, have been reported in cognitively normal individuals in an age-dependent manner. A high frequency of amyloid deposition among cognitively normal, aged individuals carrying the APOE ε4 allele has been demonstrated. This suggests that APOE ε4 facilitates amyloid deposition during the very early phase of AD pathogenesis. Preventive intervention by using disease-modifying drugs is now being investigated through an exploratory clinical trial for the cognitively normal, aged individuals with the APOE ε4 allele.


Copyright © 2016, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

関連文献

もっと見る

文献を共有