BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 9 (September 2018)

The Role of the Habenula in Depression: A Review of the Human fMRI Studies Atsuo Yoshino 1 , Hidenori Aizawa 2 , Masahiro Takamura 1 , Naho Ichikawa 1 , Chiyo Shibasaki 1 , Yosuke Yamawaki 3 , Takafumi Sasaoka 4 , Yasumasa Okamoto 1 , Shigeto Yamawaki 4 1Department of Psychiatry and Neurosciences, Hiroshima University 2Department of Neurobiology, Hiroshima University 3Department of Cellular and Molecular Pharmacology, Institute of Biomedical and Health Sciences, Hiroshima University 4Office of Academic Research and Industry-Academia-Government and Community Collaboration, Hiroshima University Keyword: 手綱核 , うつ病 , MRI , 報酬予測誤差 , habenula , depression , reward prediction errors pp.1017-1023
Published Date 2018/9/1
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Depression has various symptoms, such as depressed mood or loss of motivation, and the pathophysiological mechanisms remain unclear. Recent studies have increased the understanding of the role of the habenula, since the habenula is reported to control the metabolism of monoamine neurotransmitters in the brain through direct projections to the ventral tegmental area and raphe nucleus. Human neuroimaging studies have been performed to attempt to clarify the mechanisms of depression. This manuscript mainly introduces human neuroimaging studies of the role of the habenula in depression.

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BRAIN and NERVE-神経研究の進歩
70巻9号 (2018年9月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院