BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 9 (September 2018)

Tryptophan Metabolites in Plasma of Patients with Depression Akikazu Takada 1 , Fumiko Shimizu 2 , Tetsuya Takao 2 1NPO “International Projects on Food and Health” 2Faculty of Life and Environmental Sciences, Showa Womens University Keyword: トリプトファン , セロトニン , キヌレニン , 単極性うつ病 , 双極性うつ病 , tryptophan , serotonin , kynurenine , monopolar depression , bipolar depression pp.1025-1031
Published Date 2018/9/1
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There are two major pathways in tryptophan metabolism. The serotonin pathway mediates mood, anxiety, memory, cognition, and is impaired in depression. The kynurenine pathways are involved in immunity, inflammation, muscle movement, and mental health. We investigated changes in tryptophan metabolites in plasma from depressed patients. Plasma levels of serotonin were very low or undetectable in patients with monopolar depression. 5-hydroxyindole acetic acid (5-HIAA)/tryptophan ratios or kynurenine/tryptophan ratios were not different between healthy controls and depressive patients, indicating rapid degradation of serotonin into 5-HIAA. However, there were no significant changes in kynurenine levels in depressed patients. It is important to examine the roles of tryptophan metabolites in monopolar and bipolar depression since both require different treatments.

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BRAIN and NERVE-神経研究の進歩
70巻9号 (2018年9月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院