Vitamin E and Alzheimer's Disease Moeko Shinohara 1 , Masahito Yamada 1 1Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science Keyword: アルツハイマー病 , 軽度認知障害 , ビタミンE , αトコフェロール , Alzheimer's disease , mild cognitive impairment , vitamin E , α-tocopherol pp.1509-1513
Published Date 2015/12/1
DOI https://doi.org/10.11477/mf.1416200330
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It has been suggested that oxidative stress may contribute to the pathogenesis of Alzheimer's disease. Vitamin E is a potent antioxidant, and the results of some epidemiological studies have suggested that high intake of vitamin E through food is inversely associated with the incidence of Alzheimer's disease. Randomized controlled studies have shown that treatment with vitamin E could delay functional decline in patients with mild to moderate Alzheimer's disease. However, vitamin E had no cognitive benefits in patients with mild cognitive impairment or in generally healthy older women. Well-designed clinical trials or preventive interventions with vitamin E are necessary to establish its efficacy as therapeutic or preventive agents for Alzheimer's disease.

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