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Clinical Phenotypes in Guillain-Barré Syndrome Michiaki Koga 1 1Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine Keyword: 臨床病型 , 臨床亜型 , 疫学 , 咽頭頸部上腕型 , 四肢遠位型 , phenotype , clinical variant , epidemiology , pharyngeal-cervical-brachial weakness , distal limb weakness pp.1313-1320
Published Date 2015/11/1
DOI https://doi.org/10.11477/mf.1416200301
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Abstract

Guillain-Barré syndrome can be classified into several phenotypes according to the type of predominantly disturbed nerve fibers, distribution of muscular weakness, and electrophysiological and pathological findings. Although several regional variants including Fisher syndrome and pharyngeal-cervical-brachial weakness were initially reported in Western researchers, many labor-intensive studies by Japanese researchers have significantly contributed to defining and highlighting these variants. This review summarizes the several regional variants of Guillain-Barré syndrome while highlighting the substantial contributions made by Japanese investigators. Furthermore, a new regional variant named "distal limb weakness" is proposed, in which regional weakness of hands and feet is observed throughout the disease course. It is considered a mild phenotype of acute axonal motor neuropathy after Campylobacter jejuni enteritis.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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