癌胎児性抗原の高値を伴った前立腺原発小細胞癌

SMALL CELL CARCINOMA OF THE PROSTATE WITH AN INCREASE OF SERUM CARTINOEMBRYONIC ANTIGEN: A CASE REPORT

　76歳男性。食思不振を主訴として受診。血清CEA高値と共に，多発性転移巣が認められ皮下結節の生検の結果，転移性小細胞癌と判明した。肺，消化器系には原発巣は認められなかった。肺小細胞癌に準じた化学療法を施行したが反応はみられず5か月後に死亡した。剖検の結果，前立腺において一部に腺癌を含み広く進展する小細胞癌が指摘され，正常腺管から小細胞癌への癌化増生過程が追跡されて前立腺原発の小細胞癌と判断された。

A 76-year old male complaining anorexia had multiple metastatic lesions with a high level of serum carcinoembryonic antigen. The biopsy of subcutaneous nodes revealed metastatic small cell carcinoma, but no abnormal findinds were detected in the lung and gastrointestinal organs. A combined chemotherapy for lung small cell carcinomas was begun but no responses were obtained and he died 5 months after the treatment. The results of autopsy revealed the presence of adenocarcinoma and small cell carcinoma in the prostate.