化学療法が奏効したホルモン不応性前立腺癌肺転移

Hormone refractory prostate carcinoma with lung metastasis that chemotherapy was remarkably effective.

68歳，男性。腰背部痛を主訴に受診。前立腺癌T4N0M1b，stageD2と診断，アンドロゲン除去療法開始。その後PSAの上昇と肺転移を認め，ホルモン不応性前立腺癌と判断し，ドセタキセル療法を開始。6コース施行後PSAの低下と肺転移巣の完全消失を認めた。ドセタキセル療法は肺転移巣に対し有効であるとの報告があり，本症例はよい適応となると考えられた。

A 68-years-old man with lumbago was admitted to our hospital. Diagnosis of prostate carcinoma stageD2,T4N0M1b was established with pathological finding of poorly differentiated adenocarcinoma,Gleason score 4＋5＝9. Androgen deprivation therapy was performed immediately,but PSA level increased again and left lung metastasis（26×37 mm）was recognized by chest CT scan. Under the diagnosis of hormone refractory prostate carcinoma,docetaxel therapy was begun. Six courses later,the lung metastasis was completely vanished. A The effectiveness of docetaxel is reported more apparent for lung metastasis therefore it was thought that the docetaxel therapy was good indication for hormone refractory prostate carcinoma with lung metastasis as in this case.