耳鼻咽喉科領域における周術期抗菌薬投与期間の検討―清潔手術例について

The Period of Prophylactic Administration of Antibiotics in Head-and-Neck Clean Surgery

I．はじめに

　術後の抗菌薬投与は，主として創部の感染予防として用いられるが，抗菌薬をどの程度の期間使用するかの報告は耳鼻咽喉科領域では少ない。

　今回われわれは，頭頸部腫瘍清潔手術において手術当日のみ抗菌薬を投与した群と，一般的な抗菌薬を5日間投与した群を比較検討した。

It is uncertain how many days we should give prophylactic administration of antibiotics. We investigated the period of prophylactic administration of antibiotics in 20 patients in head-and-neck clean surgery. We compared them in two groups. A group of 8 patients was given cefazolin（CEZ）during 30minutes before the surgical incision. B group of 12 patients was given twice-daily CEZ for 5 days.

　No postoperative infection was observed in both groups. There were no statistically significant differences between both groups in the number of WBC,neutrophilic cells,value of C-reactive protein and body temperature on the 1^stto 5^thpostoperative day.

　The results indicated that only one administration of prophylactic antibiotics before the incision may control postoperative infection in the head-and-neck clean surgery.