Plasma levels of ofloxacin after topical instillation in various age groups Kayoko Matsumura 1 , Shinzou Inoue 2 , Hajime Ibuki 3 , Hideo Takashina 3 1Dept of Ophthalmol, National Kagawa Children's Hosp 2Dept of Ophthalmol, National Zentsuji Hosp 3Cent Research Labo, Santen Pharmaceutical Co Ltd pp.1265-1268
Published Date 1991/7/15
DOI https://doi.org/10.11477/mf.1410908399
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We quantitated the concentration of ofloxacin inthe circulating blood after a single instillation ofofloxacin ophthalmic solution into the cul-de-sac.Out of 95 samples from 34 adults, only one sampleshowed serum concentration of 15.1 ng/ml. Oflox-acin could not be detected in the other 94 samples.Out of 26 samples from 26 persons aged between 2months and 14 years, serum concentration of 5.7ng/ml was detected in one sample from a 4-year-boy. Ofloxacin could not be detected in the other25 samples. Out of 39 samples from 25 prematureand 1 newborn babies, ofloxacin was detected in thecirculating blood at various levels from 5.0 to 20.3ng/ml in 20 samples. Ofloxacin could not be detect-ed in the other 19 samples. One serum sample fromthe newborn showed 10.5 ng/ml of ofloxacin. Thefindings show that the serum and blood concentra-tion of ofloxacin is remarkably low after a singletopical instillation. Ophthalmic solution of oflox-acin would also be innocuous when used in pre-mature babies.

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