Bowen病の臨床像の検討

Clinical features of Bowen disease

　過去8年間にBowen病と確定した球結膜腫瘍の自検例5例5眼につき，その臨床像を検索した。男性2例，女性3例で，年齢は47歳から89歳，平均73歳であった。初発症状は結膜充血3例と眼異物感2例で、病変は角結膜の鼻側に多かった。病理学的には全例が上皮内癌であった。全例で腫瘍を摘出し，2例で表層角膜移植術，1例で結膜被覆術を併用した。腫瘍摘出のみを行った34歳女性では3か月後に両発し，再手術を行った。3か月から24か月，平均14.8か月の経過観察期間中，全例が生存した。

We reviewed 5 eyes of 5 cases of conjunctival tumor that were eventually diagnosed with Bowen disease during the past 8 years. The series comprised 2 males and 3 females. Their ages ranged from 47 to 89 years, average 73 years. The initial symptoms comprised conjuntival hyperemia 3 eyes and foreign body sensation 2 eyes. The con-junctiva nasal to the cornea was the predilected site of occurrence. Histopathology showed carcinoma in situ in all the eyes. All the 5 eyes were treated by extirpation of the tumor. Additional lamellar keratoplasty was performed in 2 eyes and repair of the wound by conjunctiva in 1 eye. The tumor recurred 3 months after simple extirpation in a 34-year-old female, requiring another surgery. All the 5 cases were doing well during the follow-up for 3 to 24 months, average 14.8 months.